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Rice plants engineered to be better at photosynthesis make more rice
You can join us by applying for one of our PhD research or fellowship opportunities. We're committed to making an impact with our research. That's why we work with our partners in industry to develop new solutions, and take part in a range of events to inspire the public. UK top 5 for biological research and No. We study life at the molecular level. We're finding exciting new approaches in bioscience and training the next generation of highly skilled scientists. Crews is the John C. He graduated from the U.
Virginia with a B. Crews has a foothold in both the academic and biotech arenas; on the faculty at Yale since , his laboratory has pioneered the use of small molecules to control intracellular protein levels. In , he co-founded Proteolix, Inc. Crews has focused on a new drug development technology, which served as the founding intellectual property for his latest New Haven-based biotech venture, Arvinas, Inc.
Currently, Dr. Crews serves on several editorial boards and was Editor of Cell Chemical Biology In , he was named an American Cancer Society Professor.
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He was a postdoctoral fellow with Paul Greengard in the Department of Pharmacology at Yale, and subsequently an assistant professor in the Yale Section of Cell Biology. Following a return of a few years to Milan, he moved back to Yale in the late s, where he is now John Klingenstein Professor of Neuroscience. The De Camilli lab is interested in the cell biology of neuronal synapses.
His studies on synaptic vesicle dynamics have contributed to the general fields of exocytosis and endocytosis. His research has provided insight into mechanisms of membrane fission and has revealed ways through which membrane-associated proteins can generate, sense and stabilize lipid bilayer curvature. His discovery and characterization of the role of phosphoinositide metabolism in the control of endocytosis have broad implications in the fields of phospholipid signaling and of membrane traffic.
Building on this work, he has recently become interested in the role of membrane contact sites in the control of the homeostasis of bilayer lipids. His studies of synapses have also contributed to the elucidation of pathogenetic mechanisms of human diseases. He continued his post-graduate training at Yale, performing internship and residency in Internal Medicine, a research post-doctoral fellowship, and a clinical fellowship in Medical Oncology.
His clinical specialty is breast cancer and he conducts both clinical and laboratory-based research. His translational laboratory research focuses on signal transduction in breast cancer. The DiMaio laboratory is studying the molecular mechanisms of how two groups of tumor viruses, human papillomaviruses and polyomaviruses, enter cells, with a particular focus on identifying the cellular proteins that mediate virus entry and intracellular trafficking and determining their molecular mechanisms of action.
In addition, it is using viral transmembrane proteins as a basis to develop a class of artificial small transmembrane proteins with a variety of biological activities, including the ability to form tumors and confer resistance to HIV infection. Some of these proteins are the simplest proteins ever described and their study will reveal new features of protein action and the basis for specificity in protein-protein interactions. Her research focuses on the functional characterization of tumor suppressor and oncogenic long non-coding RNAs and their roles in the regulation of the cancer transcriptome.
Originally from Sofia, Bulgaria, Nadya graduated with an Sc. She joined the graduate program at The Rockefeller University and in received a Ph.see
Titia de Lange. For her graduate work, Nadya was awarded the Harold M. Weintraub Graduate Student Award. As a postdoctoral fellow, Nadya joined the laboratory of Dr. My lab studies animal evolution, with a particular focus on better understanding our most distant animal relatives and the earliest events in the animal tree of life.
Our research includes field work to collect poorly known animals, often by SCUBA diving and sometimes with remotely operated underwater vehicles. Lab bench work includes studies of anatomy and genome function. Much of my work is computational- we develop methods and tools for analyzing evolutionary relationships and using those relationships to provide an integrated perspective on genomic and anatomical evolution. I coauthored the book Practical Computing for Biologists to help more biologists become comfortable with computational methods.
In addition to his studies of broad patterns of diversity across distantly related animals, my lab also focuses on siphonophores, a group of about species of open-ocean animals that include the Portuguese Man of War. We address basic questions about their structure, growth, diversity, and evolution. The goal of research in my lab is to understand how the status of lysosomes is sensed and how lysosomal function is regulated to meet cellular demands.
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Conversely, lysosomes are critical for the turnover and clearance from cells of damaged organelles and protein aggregates. Furthermore, the role played by lysosomes in sensing cellular energy and nutrient levels and transducing this information into signals controlling growth represents a potential therapeutic target in cancer.
With this growing appreciation of the roles played by lysosomes in health and disease, we ultimately seek to address the following fundamental questions:. A How do cells sense and regulate the status of their lysosomes? C Can lysosomal function be modulated for therapeutic purposes? To address these questions we combine live cell imaging to monitor the dynamic recruitment of proteins to lysosomes with proteomic approaches to define the molecular basis for this recruitment and high-throughput siRNA screening to identify new mechanisms controlling lysosomal homeostasis.
Insights obtained through these strategies will contribute to answering fundamental cell biological questions concerning organelle homeostasis and are expected to be of direct relevance to human health. Lucille P. Jorge E. He completed postdoctoral studies at Washington University in St. He is currentlythe Lucille B. Cruickshank Award, and the Robert Koch Prize. He is a member of several Scientific Advisory Boards and has authored more than publications in the field of bacterial pathogenesis and molecular biology.
Professor Gendron has 18 years of experience studying the genetic and molecular basis of how organisms react to environmental cues. He performed his Ph. In addition, he described how brassinosteroids control growth and organogenesis. He performed his post-doctoral research in Dr. He was funded by a Ruth L. Furthermore, he spent one year as a visiting scholar in the laboratory of Dr.
Eric Bennett at University of California, San Diego studying mammalian protein degradation mechanisms and learning mass spectrometry techniques and analysis. As an assistant professor at Yale University, he runs a research program that reveals the interplay of protein degradation and daily timing mechanisms in eukaryotes using reverse genetics and biochemistry in the model plant Arabidopsis. His work impacts our understanding of how plants sense and respond to environmental cues with the goal of making crops robust to rapidly changing climates. The work in the laboratory is supported by the National Science Foundation.
The work in the Gendron lab focuses on how protein degradation controls the circadian clock in plants. The lab using protein engineering, mass spectrometry, and forward and reverse genetic approaches to investigate how the ubiquitin proteasome system couples the circadian clock to downstream biological processes such as metabolism, cell growth, and cell differentiation.
After graduating from Harvard with a A. Mark Gerstein earned a doctorate in theoretical chemistry and biophysics from Cambridge University in He did postdoctoral research in bioinformatics at Stanford University from to He came to Yale in as an assistant professor in the Department of Molecular Biophysics and Biochemistry, and since , in the Computer Science Department.
He was named an associate professor in , and the following year became co-director of the Yale Computational Biology and Bioinformatics Program. Antonio established his laboratory at Yale in where he investigates the regulatory codes that shape gene expression during embryonic development. Robert E.
Radiation oncologist Peter M. He has dedicated his career to helping cancer patients receive the highest quality of care available in a supportive environment. Glazer makes it his priority to provide patients seeking care at Smilow Cancer Hospital and its Care Centers with the most advanced technologies and evidence-based treatments.
As a professor of both therapeutic radiology and genetics at Yale School of Medicine, Dr. Glazer researches new therapeutic strategies for treating cancer and the role of altered DNA repair in tumor progression.
Henry J. After completing medical school and internal medicine training at the University of Missouri, Dr. Gorelick trained at Yale in Gastroenterology. After his clinical training, he began basic science training with Dr. James Jamieson at Yale. During that period he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard Rockefeller University to examine the enzyme's mechanism of activation, a response critical to neuronal memory.